Bioactive Small Molecules
![Medchemexpress LLC Benzamide, 3,5-difluoro-N-[4-[(1R)-1-methyl-2-[[(1-methylethyl)sulfonyl)amino]ethyl]phenyl]- | 376594-67-1 | 99.51% | 396.45 | 50 MG](https://assets.fishersci.com/TFS-Assets/CCG/product-images/default.jpg-250.jpg)
Medchemexpress LLC Benzamide, 3,5-difluoro-N-[4-[(1R)-1-methyl-2-[[(1-methylethyl)sulfonyl)amino]ethyl]phenyl]- | 376594-67-1 | 99.51% | 396.45 | 50 MG
LY450108 is a potent AMPA receptor potentiator with potential applications in research related to depression and Parkinson's disease. AMPA receptors are crucial for excitatory neurotransmission and synaptic plasticity in the mammalian central nervous system. Beyond modulating fast synaptic plasticity and memory, AMPA receptor potentiators can influence downstream signaling pathways.
- Target: AMPA receptor potentiator
- Research applications: Potential for depression and Parkinson's disease research
- Form: Solid, white to off-white appearance
- Solubility: Soluble in DMSO (≥ 50 mg/mL), insoluble in H₂O (< 0.1 mg/mL)
- Storage: Powder at -20°C for 3 years, 4°C for 2 years. In solvent, -80°C for 2 years, -20°C for 1 year
Medchemexpress LLC Magnesium silicate (activated magnesium silicate) | 1343-88-0 | MFCD00078249 | 25 G
Magnesium silicate (activated magnesium silicate) | 1343-88-0 | MFCD00078249 | 25 G
TARGETMOL CHEMICALS INC ICARITIN 10MG
Also available in 1 mg 5 mg 25 mg 50 mg 100 mg 1 mL 10 mM (in DMSO) and bulk. Please contact Fisher for quotes. Icaritin (Anhydroicaritin) has hormone regulation activity and cardiovascular function improvement activity. Icaritin has anticancer activity can induce S phase arrest and apoptosis inhibit ENKL cell proliferation. Icaritin has anti-multiple myeloma activity mainly mediated by inhibiting IL-6/JAK2/STAT3 signaling. Icaritin at low concentration (4 or 8 uMol/L) can promote rat chondrocyte proliferation and inhibit cell apoptosis while the effect of Icaritin on rat chondrocyte at high concentration was reversed. purity: 98%
Selleck Chemical LLC Retatrutide P1230-25MG
Retatrutide (LY3437943) acts as a triple agonist peptide of the glucagon receptor (GCGR) glucagon-like peptide-1 receptor (GLP-1R) and glucosedependent insulinotropic polypeptide receptor (GIPR) Retatrutide binds to human GCGR GLP-1R and GIPR with EC50 values of 5 79 0 775 nM and 0 0643 respectively Retatrutide has the potential for use in research on obesity
Medchemexpress LLC α-Hydroxyglutaric acid-d4 disodium | 2483831-91-8 | 95.9% | 196.10 g/mol | C5H2D4Na2O5 | 5 MG
α-Hydroxyglutaric acid-d4 disodium is the deuterium-labeled disodium salt of α-hydroxyglutaric acid (2-hydroxyglutarate), provided as a stable isotope internal standard or tracer for research applications in metabolomics and epigenetics. The material is supplied with characterization documents and is intended for research use only.
Cayman Chemical ANTIBODY YL-109 50mg
An anticancer agent; inhibits the proliferation of MCF-7 and MDA-MB-231 cells (IC50s = 0.0858 and 4.2 µM, respectively), as well as migration and invasion by MDA-MB-231 cells in vitro; induces expression of CHIP in MDA-MB-231 cells in an AHR-dependent manner; inhibits MDA-MB-231-derived CSC mammosphere formation at 1 µM; reduces tumor volume and the number of metastases in an MDA-MB-231 mouse xenograft model at 15 mg/kg
AdipoGen Rifamycin O
Chemical. CAS 14487-05-9. Formula C39H47NO14. MW 753.8. Semisynthetic. Ansamycin antibiotic. Selective inhibitor of bacterial DNA-dependent RNA polymerase RNAP. Effective against mycobacteria, and are therefore used in research of tuberculosis, leprosy and mycobacterium avium complex MAC infections.
Cayman Chemical ANTIBODY CemEC1 5mg
A selective inhibitor of TAF1 bromodomain 2 (Kd = 1.8 µM; IC50 = 0.9 µM); synergizes with (+)-JQ1 to inhibit the proliferation of THP-1 and H23 lung adenocarcinoma cells
Medchemexpress LLC HY-128656 5mg Medchemexpress, LML134 CAS:1542135-76-1 Purity:>98%
Medchemexpress, HY-128656 5mg LML134 CAS:1542135-76-1 LML134 (compound 18b) is an orally active and high selective Histamine 3 receptor (H3R) inverse agonist with Kis of 0.3 nM and 12 nM for hH3R cAMP and hH3R bdg. LML134 penetrates the brain rapidly, leading to high H3R occupancy, and disengages its target with a fast kinetic profile. LML134 has the potential for excessive sleep disorders. Purity:>98% Medchemexpress has over 10000 novel life-science reagents, reference compounds, APIs and natural compounds for laboratory and scientific use. Other quantity can also be offered.
AdipoGen Manumycin B
Chemical. CAS 139023-58-8. Formula C28H34N2O7. MW 510.6. Isolated from Streptomyces parvulus. Antibiotic. Antibacterial. Active against Gram-positive bacteria. Rasfarnesyltransferase inhibitor. Apoptosis Caspase-1 inhibitor. AChE inhibitor.
Cayman Chemical Fura-2potasIum salt 5mg
A ratiometric fluorescent calcium indicator; em = 510 nm; ex = 340 and 380 nm at high and low calcium concentrations, respectively; enables determination of ratiometric measurements of calcium influx in live cells
Cayman Chemical ANTIBODY NS 1619 5mg
A calcium-dependent activator of BKCa channels that is typically used at a concentration of 30 µM to hyperpolarize the membrane potential of single myocytes during studies of smooth muscle relaxation and vasodilation; cardioprotective against pulmonary hypertension as well as ischemia and reperfusion injury in various animal models
Cayman Chemical ANTIBODY CAY17c 1mg
An inhibitor of BRD4 and class I and class IIb HDACs; inhibits BRD4 (IC50 = 0.71 µM), as well as class I HDACs (IC50s = 0.046, 0.058, 0.075, and 0.167 µM for HDAC1, -2, -3, and -8, respectively) and class IIb HDACs (IC50s = 0.073 and 0.923 µM for HDAC6 and HDAC10, respectively); selective for these enzymes over BRD2, -3, and -T (IC50s = >20 µM for all), as well as over HDAC4, -5, -7, -9, and -11 (IC50s = >10 µM for all); inhibits proliferation of HCT116, SW620, and DLD-1 cells (IC50s = 0.45, 1.78, and 2.11 µM, respectively); induces apoptosis and autophagy in HCT116 cells; reduces tumor growth in an HCT116 mouse xenograft model at 15 and 30 mg/kg
Cayman Chemical DREADD AgonIst 21 10mg
Selectively activates hM3Dq (EC50 = 1.7 nM), a DREADD derived from the human muscarinic acetylcholine M3 receptor
Cayman Chemical ANTIBODY APY-29 10mg
A modulator of IRE1α function; binds to the ATP-binding site on IRE1α, where it inhibits autophosphorylation (IC50 = 280 nM) and enhances its RNase function (EC50 = 460 nM); restores the ability of dephosphoylated IRE1α to cleave XBP1 mRNA in a dose-dependent manner; enhances IRE1α oligomerization in a crosslinking assay